The best way of diagnosing Trisomy 21 during second trimester of pregnancy is:

Correct Answer: Amniocentesis
Description: The main use is in diagnosing chromosomal disorders like trisomy 21.Amniotic fluid cells are cultured and karyotyping done,which may take up to 3 weeks (refer pgno:502 sheila textbook of obstetrics 2 nd edition)
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