**Core Concept**
The question is testing the knowledge of antifungal medications used to treat systemic fungal infections in humans. Systemic fungal infections are a serious condition that can be life-threatening if left untreated. The antifungal drug used for systemic fungal infection should have a broad spectrum of activity, be effective against multiple fungal pathogens, and have a favorable safety profile.

**Why the Correct Answer is Right**
The correct answer is **Amphotericin B**. Amphotericin B is a polyene antifungal medication that works by binding to the sterol ergosterol in the fungal cell membrane, ultimately leading to the formation of pores and cell death. It is effective against a wide range of fungal pathogens, including Aspergillus, Candida, and Histoplasma. Amphotericin B is administered intravenously and is commonly used to treat systemic fungal infections such as invasive aspergillosis, candidemia, and cryptococcal meningitis.

**Why Each Wrong Option is Incorrect**
**Option A:** Fluconazole is a triazole antifungal medication that is effective against many fungal pathogens, but it is primarily used to treat mucocutaneous fungal infections and not systemic fungal infections.

**Option B:** Griseofulvin is an antifungal medication that is effective against dermatophytes, but it is not effective against systemic fungal infections.

**Option C:** Voriconazole is a triazole antifungal medication that is effective against many fungal pathogens, but it is not the first-line treatment for systemic fungal infections.

**Clinical Pearl / High-Yield Fact**
Amphotericin B can cause nephrotoxicity, which is a common side effect of this medication. It is essential to monitor renal function closely when administering amphotericin B.

**Correct Answer: C. Voriconazole is a triazole antifungal medication that is effective against many fungal pathogens, but it is not the first-line treatment for systemic fungal infections.