The 1st product of tryptophan catabolism is?
Correct Answer: Kynurenine
Description: Tryptophan is degraded to amphibolic intermediates via the kynurenine-anthranilate pathway. Tryptophan oxygenase (tryptophan pyrrolase) opens the indole ring, incorporates molecular oxygen, and forms N-formyl kynurenine.
Hydrolytic removal of the formyl group of A T -formylkynurenine, catalyzed by kynurenine formylase, produces kynurenine. Since kynureninase requires pyridoxal phosphate, excretion of xanthurenate in response to a tryptophan load is diagnostic of vitamin B6. deficiency.
Hartnup disease reflects impaired intestinal and renal transport of tryptophan and other neutral amino acids
Category:
Biochemistry
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