The 10-year-old boy with gross hematuria, loin pain, diarrhea urine examination is normal. Serum C3 levels are normal diagnosis is –
Correct Answer: Berger's disease
Description: Ans-A i.e., Berger's disease PSGNAbrupt onset of hematuria, oliguria, edema & hypertension.Following infection by group A beta-hemolytic streptococci.Throat strain 4 & 12, skin strain-49Granular deposition of IgG & C3 level.C, the level is a decreaseMicroangiopathic hemolytic anemiaAlso known as HUS (Hemolytic uremic syndrome)Acute diarrhea or dysentery followed by sudden onset of pallor, oliguria, seizure, altered sensoriumMicroscopic hematuria, mild proteinuria, thrombocytopeniao IgA Nephropathy ( Berger Nephropathy)IgA nephropathy is the most common chronic glomerular disease worldwide.It is characterized by a predominance of IgA within mesangial deposits of the glomerulus in the absence of systemic diseases such as systemic lupus erythematosus or Henoch-Schonlein purpura.Focal and segmental mesangial! proliferation and increased mesangial matrix are seen in the glomerulus. Some children display generalized mesangial proliferation that may be associated with the crescent formation and scarring. IgA is the predominant immunoglobulin deposited in the mesangiumIgA nephropathy is seen more often in males than in females.Gross hematuria often occurs in association with an upper respiratory> or gastrointestinal infection and may be associated with loin pain.Mild to moderate hypertension is most often seen in patients with nephritic or nephrotic syndrome but is rarely severe enough to result in hypertensive emergencies.Normal serum levels of C3 in IgA nephropathy help to distinguish this disorder from poststreptococcal glomerulonephritis.
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