True statement about tetracycline is
**Core Concept**
Tetracyclines are a class of broad-spectrum antibiotics that exert their bacteriostatic effect by inhibiting protein synthesis in susceptible microorganisms. However, tetracyclines also possess other unique properties that contribute to their pharmacological profile.
**Why the Correct Answer is Right**
Tetracyclines have a chelating property, which enables them to bind to metal ions such as calcium and magnesium. This property is crucial for their mechanism of action, as it allows them to inhibit protein synthesis by binding to the 30S subunit of the bacterial ribosome. However, the chelating property of tetracyclines also contributes to their potential side effects, such as tooth discoloration and inhibition of bone growth. The chelating property of tetracyclines is due to the presence of a hydroxyl group in the molecule, which forms a stable complex with metal ions.
**Why Each Wrong Option is Incorrect**
**Option A:** This statement is incorrect because tetracyclines actually bind to the 30S subunit of the bacterial ribosome, not the 50S subunit. The 50S subunit is the target of macrolides, such as erythromycin.
**Option C:** This statement is incorrect because tetracyclines do not have anabolic activity. Anabolic agents, such as testosterone and growth hormone, promote growth and development, whereas tetracyclines inhibit protein synthesis.
**Option D:** This statement is incorrect because tetracyclines are actually frequently responsible for superinfection. Superinfection occurs when the use of antibiotics disrupts the normal flora of the body, allowing opportunistic pathogens to overgrow and cause infection.
**Clinical Pearl / High-Yield Fact**
Tetracyclines can cause tooth discoloration in children and adolescents due to their chelating property, which binds to calcium and inhibits the mineralization of teeth. This is a classic exam trap, and students should remember to advise patients to use tetracyclines with caution in this age group.
**β Correct Answer: B. Tetracyclines have chelating property**