**Core Concept:** Procaine is a local anesthetic drug, which belongs to the aminoamide group of local anesthetics. It works by inhibiting voltage-gated sodium channels in the neuron membrane, preventing the initiation and conduction of action potentials, and thus blocking pain transmission.

**Why the Correct Answer is Right:** Procaine is a local anesthetic drug that exerts its effects by inhibiting voltage-gated sodium channels in the neuronal membrane. This inhibition prevents the initiation and conduction of action potentials, resulting in the blockage of pain transmission.

**Why Each Wrong Option is Incorrect:**

A. This option is incorrect because procaine does inhibit voltage-gated sodium channels, which is its primary mode of action as a local anesthetic.

B. This option is incorrect because procaine does not possess anti-inflammatory properties; it is primarily a local anesthetic.

C. This option is incorrect as procaine does inhibit voltage-gated sodium channels, which is its primary mode of action as a local anesthetic.

D. This option is incorrect because procaine does inhibit voltage-gated sodium channels, as mentioned earlier, making it a local anesthetic agent.

**Clinical Pearl:** Procaine is commonly used in combination with other local anesthetic agents, such as adrenaline, to improve its duration and reduce its toxicity. This combination is known as "Novocaine" or "Novocain."

**Correct Answer:** C. Procaine is terminated by esterases.

Esters are biotransformed by esterases, a group of enzymes present in the blood plasma and tissues. Esterases cleave the ester linkage in procaine, breaking down the molecule into its constituent parts: para-aminoclonidine and p-aminobenzoic acid. This biotransformation eliminates procaine from the body, thus terminating its activity.