**Core Concept**
Microarray technology is a high-throughput technique used for gene expression analysis, genetic variation detection, and comparative genomic hybridization. Although microarrays can detect chromosomal copy number variations, they are not typically used for detecting specific aneuploidies.

**Why the Correct Answer is Right**
Microarray analysis involves hybridizing labeled cDNA or RNA samples to a glass slide or microchip containing thousands of probes. While microarrays can identify chromosomal regions with copy number variations, they are not as specific or sensitive as other techniques for detecting specific aneuploidies. Unlike FISH, RT-PCR, and QF-PCR, microarrays do not use locus-specific probes to directly detect the presence or absence of specific chromosomes or chromosomal segments.

**Why Each Wrong Option is Incorrect**
**Option A:** Fluorescence In Situ Hybridization (FISH) is a technique that uses labeled probes to detect specific DNA sequences or chromosomal regions, making it useful for detecting specific aneuploidies.
**Option B:** Real-Time Polymerase Chain Reaction (RT-PCR) is a highly sensitive and specific technique for detecting specific DNA sequences, including those associated with aneuploidies.
**Option C:** Quantitative Fluorescent Polymerase Chain Reaction (QF-PCR) is a rapid and sensitive technique for detecting specific aneuploidies, particularly in prenatal diagnosis.

**Clinical Pearl / High-Yield Fact**
When diagnosing aneuploidies, it's essential to choose a technique that balances specificity, sensitivity, and cost-effectiveness. FISH, RT-PCR, and QF-PCR are valuable tools for detecting specific aneuploidies, while microarray analysis is more suited for identifying chromosomal copy number variations.

**✓ Correct Answer: D. Microarray**