Systemic steroid cause all except –
**Core Concept**
Systemic steroids have various effects on the body due to their anti-inflammatory and immunosuppressive properties. They can cause a range of side effects, including metabolic, endocrine, and musculoskeletal changes.
**Why the Correct Answer is Right**
Systemic steroids can cause weight gain, osteoporosis, and glucose intolerance due to their effects on lipid metabolism, bone resorption, and insulin resistance. This is because steroids induce the transcription of genes involved in gluconeogenesis and lipogenesis, leading to increased glucose and lipid production. Furthermore, steroids can also cause adrenal suppression by inhibiting the production of cortisol and other glucocorticoids.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because systemic steroids do indeed cause weight gain, which is a well-documented side effect.
**Option B:** This option is incorrect because osteoporosis is a known consequence of long-term steroid use, resulting from increased bone resorption.
**Option C:** This option is incorrect because glucose intolerance is a recognized side effect of systemic steroids, which can lead to insulin resistance and hyperglycemia.
**Clinical Pearl / High-Yield Fact**
To minimize the risk of osteoporosis, patients on long-term steroid therapy should be counseled on lifestyle modifications, including adequate calcium and vitamin D intake, regular exercise, and smoking cessation.
**Correct Answer: D.**