Systemic sclerosis shows all except –
**Core Concept**
Systemic sclerosis, also known as scleroderma, is a chronic autoimmune disease characterized by **fibrosis** and **vascular alterations** in the skin and internal organs. The disease involves an interplay of immune, vascular, and fibrotic pathways.
**Why the Correct Answer is Right**
Since the options are not provided, let's discuss the general characteristics of systemic sclerosis. It typically presents with **Raynaud's phenomenon**, followed by skin thickening and fibrosis. The disease can affect various organs, including the lungs, heart, kidneys, and gastrointestinal tract, leading to complications such as pulmonary hypertension and renal crisis.
**Why Each Wrong Option is Incorrect**
Without specific options, it's challenging to address each choice directly. However, common manifestations of systemic sclerosis include skin thickening, **esophageal dysmotility**, and pulmonary involvement, which can help in identifying incorrect options.
**Clinical Pearl / High-Yield Fact**
A key point to remember is that systemic sclerosis can be categorized into limited and diffuse forms, with the latter having a more rapid progression and poorer prognosis.
**Correct Answer:** Not provided due to missing options.