**Core Concept**
ApoE (Apolipoprotein E) and ApoC are proteins involved in lipid metabolism, playing crucial roles in the transport and clearance of lipids in the body. They are components of lipoproteins, which are complex molecules that transport lipids, including cholesterol and triglycerides.

**Why the Correct Answer is Right**
ApoE and ApoC are synthesized in the liver. ApoE is involved in the clearance of lipids from the bloodstream, particularly in the uptake of chylomicron remnants by the liver. ApoC, on the other hand, is involved in the regulation of triglyceride-rich lipoproteins, such as VLDL (Very Low-Density Lipoprotein). The liver synthesizes both ApoE and ApoC, which are then secreted into the bloodstream, where they bind to lipoproteins and modulate their metabolism.

**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect because while ApoE and ApoC are indeed involved in lipid metabolism, they are not synthesized in the kidneys.
**Option B:** Incorrect because although the intestines do play a role in lipid metabolism, they do not synthesize ApoE and ApoC.
**Option C:** Incorrect because the pancreas is primarily involved in glucose metabolism, not lipid metabolism.

**Clinical Pearl / High-Yield Fact**
ApoE is a key player in the clearance of cholesterol from the bloodstream, and variations in the ApoE gene have been associated with an increased risk of atherosclerotic cardiovascular disease.

**Correct Answer:** C. Liver.