**Core Concept**
Down's Syndrome, Klinefelter's Syndrome, and Patau Syndrome are known to be associated with an increased risk of developing Acute Myeloid Leukemia (AML). This is due to genetic instability and alterations in the hematopoietic system. Individuals with these syndromes often have a higher propensity for leukemogenesis.

**Why the Correct Answer is Right**
Turner's Syndrome, on the other hand, is primarily associated with an increased risk of developing lymphoid malignancies, such as lymphoma. The genetic abnormalities characteristic of Turner's Syndrome, including monosomy X, do not significantly contribute to the development of AML. In contrast, the other options are linked to specific genetic anomalies that predispose individuals to AML.

**Why Each Wrong Option is Incorrect**
**Option A:** Down's Syndrome is associated with trisomy 21, which leads to overexpression of the GATA1 gene, contributing to the development of AML.
**Option B:** Klinefelter's Syndrome is characterized by XXY karyotype, which increases the risk of developing AML due to the disruption of normal X-chromosome inactivation.
**Option C:** Patau Syndrome, caused by trisomy 13, results in the overexpression of certain genes that contribute to the development of AML.

**Clinical Pearl / High-Yield Fact**
It is essential to recognize the increased risk of AML in individuals with Down's Syndrome, Klinefelter's Syndrome, and Patau Syndrome, as early detection and treatment can significantly improve outcomes.

**✓ Correct Answer: D. Turner's Syndrome**