**Core Concept**
Sjögren's syndrome is a chronic autoimmune disorder characterized by lymphocytic infiltration and destruction of exocrine glands, particularly the salivary and lacrimal glands, leading to symptoms of dry mouth (xerostomia) and dry eyes (xerophthalmia).

**Why the Correct Answer is Right**
The correct answer is **C. Parotid gland biopsy preferred** because in Sjögren's syndrome, the minor salivary gland (submandibular or labial) biopsy is the preferred diagnostic method. The minor salivary gland biopsy is more sensitive and specific than parotid gland biopsy for diagnosing Sjögren's syndrome. This is because the minor salivary glands are more frequently affected and show more pronounced histopathological changes.

**Why Each Wrong Option is Incorrect**
**Option A:** Keratoconjunctivitis sicca is a correct association with Sjögren's syndrome, as it is characterized by dry eyes. However, it is not the false statement.

**Option B:** Periductal and perivascular lymphocytic infiltration is a correct histopathological feature of Sjögren's syndrome, particularly in the salivary glands.

**Option D:** MALToma (Mucosa-Associated Lymphoid Tissue lymphoma) is a common type of lymphoma associated with Sjögren's syndrome, but it is not the most common type.

**Clinical Pearl / High-Yield Fact**
To diagnose Sjögren's syndrome, clinicians should focus on minor salivary gland biopsy as the preferred diagnostic method, as it is more sensitive and specific than parotid gland biopsy. Additionally, a Schirmer's test can be used to assess tear production in patients with suspected Sjögren's syndrome.

**✓ Correct Answer: C. Parotid gland biopsy preferred**