Regarding Good pasture’s syndrome all are true except
**Core Concept**
Goodpasture's syndrome is a rare autoimmune disorder characterized by the presence of autoantibodies against the collagen type IV alpha3 chain of the glomerular basement membrane (GBM) and pulmonary capillaries. This leads to damage of the renal and pulmonary tissues, resulting in kidney failure and lung hemorrhage.
**Why the Correct Answer is Right**
Goodpasture's syndrome is a rapidly progressive glomerulonephritis, typically leading to acute kidney injury and renal failure within weeks to months. The rapid progression of renal failure is a hallmark of the disease, distinguishing it from other causes of kidney damage.
**Why Each Wrong Option is Incorrect**
**Option A:** Goodpasture's syndrome is indeed an autoimmune disease, so this statement is true.
**Option B:** The autoantibodies in Goodpasture's syndrome specifically target the collagen type IV alpha3 chain of the GBM and pulmonary capillaries, making this statement true.
**Option C:** Patients with Goodpasture's syndrome often present with diffuse bilateral pulmonary infiltrates, which can be seen on chest imaging, making this statement true.
**Why Each Wrong Option is Incorrect (continued)**
**Option D:** This statement is incorrect because Goodpasture's syndrome is characterized by rapidly progressive renal failure, not slowly progressive renal failure.
**Clinical Pearl / High-Yield Fact**
A key feature of Goodpasture's syndrome is the presence of anti-GBM antibodies, which can be detected in the serum of affected patients. This test can help confirm the diagnosis and guide treatment.
**Correct Answer Line**
β Correct Answer: D. Slowly progressive Renal failure