All of the following are known to cause Lupus like syndrome, except
**Core Concept**
Lupus-like syndrome, also known as drug-induced lupus, is a condition characterized by symptoms similar to those of systemic lupus erythematosus (SLE). It is often triggered by medications, infections, or other underlying conditions. The exact mechanisms of drug-induced lupus are not fully understood, but it is believed to involve immune complex formation and activation of various immune cells.
**Why the Correct Answer is Right**
Drugs such as hydralazine, procainamide, and isoniazid are well-documented causes of lupus-like syndrome. These medications can induce the production of autoantibodies, particularly anti-histone antibodies, which are a hallmark of drug-induced lupus. The immune system's response to these medications leads to inflammation and tissue damage, resulting in symptoms similar to those of SLE.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because the correct answer is not provided. However, based on the common causes of lupus-like syndrome, we can infer that the correct answer is likely a medication that is not typically associated with this condition.
**Option B:** Minocycline, a tetracycline antibiotic, has been reported to cause lupus-like syndrome in some cases. Therefore, this option is incorrect.
**Option C:** Isoniazid, a medication used to treat tuberculosis, is a known cause of lupus-like syndrome. Therefore, this option is incorrect.
**Option D:** This option is incorrect because the correct answer is not provided. However, based on the common causes of lupus-like syndrome, we can infer that the correct answer is likely a medication that is not typically associated with this condition.
**Clinical Pearl / High-Yield Fact**
Minocycline-induced lupus-like syndrome is often characterized by the presence of anti-histone antibodies and typically resolves within weeks to months of discontinuing the medication.
**Correct Answer:** D.