**Question:** Which one of the following is a distinguishing feature of Edward's syndrome?

A. Short stature
B. Epicanthal folds
C. Hypoplastic nails
D. Cleft lip and palate

**Core Concept:** Edward's syndrome, also known as Edwards syndrome, is a rare genetic disorder characterized by the presence of multiple congenital abnormalities. It is a type of trisomy, specifically trisomy 18, which occurs due to the presence of an extra copy of chromosome 18 in the affected individual's cells.

**Why the Correct Answer is Right:**
Edward's syndrome is a result of an extra copy of chromosome 18, and its distinguishing feature is the presence of multiple congenital abnormalities. In this case, one of the features is **Hypoplastic nails**. Hypoplastic nails are underdeveloped or abnormally shaped nails, which are often seen in individuals with trisomy syndromes, including Edward's syndrome.

**Why Each Wrong Option is Incorrect:**
A) **Short stature** is a feature of some other genetic disorders, not specifically Edward's syndrome.
B) **Epicanthal folds** are a feature of East Asian ancestry and are not directly linked to Edward's syndrome.
D) **Cleft lip and palate** can be a feature of some genetic syndromes, but not exclusively associated with Edward's syndrome.

**Clinical Pearl:**
Edward's syndrome is a critical concept for medical students and practicing physicians, as it highlights the importance of genetic counseling and prenatal diagnosis. Understanding the clinical features of syndromes can help in early diagnosis, management, and support to affected individuals and their families.