Syndrome associated with deafness is:
**Core Concept**
The question is testing knowledge of the association between specific syndromes and their characteristic manifestations, particularly deafness. This requires an understanding of the genetic and clinical features of various syndromes.
**Why the Correct Answer is Right**
The correct answer is associated with Waardenburg syndrome, a rare genetic disorder characterized by congenital sensorineural deafness, white forelock, and pigmentation anomalies of the skin and hair. The syndrome is caused by mutations in the PAX3 gene, which plays a crucial role in the development of the auditory system and melanocytes. The genetic defect leads to a disruption in the migration and differentiation of neural crest cells, resulting in congenital deafness and other associated features.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not specify a syndrome associated with deafness. While there are several conditions that can cause hearing loss, this option lacks the necessary detail to be correct.
**Option B:** This option is incorrect because it is not a recognized syndrome associated with deafness. While some genetic conditions can cause hearing loss, this option does not accurately represent a specific syndrome.
**Option C:** This option is incorrect because it is not directly associated with deafness. While some syndromes may have hearing loss as a secondary feature, this option does not represent a primary association with deafness.
**Clinical Pearl / High-Yield Fact**
Waardenburg syndrome is a rare genetic disorder that highlights the importance of genetic testing in patients with congenital deafness. A high index of suspicion and early genetic counseling can significantly improve patient outcomes.
**Correct Answer: C. Waardenburg syndrome**