Patients has G6PD deficiency often have an increased susceptibility to infection, which in turn may precipitate a hemolytic episode. What is the most likely underlying mechanism for the increased risk of infection?
**Core Concept**
The underlying principle being tested is the relationship between **G6PD deficiency** and increased susceptibility to infection, which can trigger hemolytic episodes. **G6PD deficiency** is a genetic disorder that affects the enzyme **glucose-6-phosphate dehydrogenase**, leading to impaired red blood cell function. This impairment makes red blood cells more vulnerable to oxidative stress.
**Why the Correct Answer is Right**
Although the options are missing, the correct answer is likely related to the impaired function of **neutrophils** or other immune cells in patients with **G6PD deficiency**. These cells rely on **NADPH** produced by the **pentose phosphate pathway**, where **G6PD** plays a crucial role, to maintain their oxidative burst and phagocytic capabilities. Without sufficient **G6PD** activity, these immune cells may not function properly, increasing the risk of infection.
**Why Each Wrong Option is Incorrect**
**Option A:** Would be incorrect because it's not directly related to the immune system dysfunction associated with **G6PD deficiency**.
**Option B:** Might be incorrect if it suggests a different, unrelated mechanism for increased infection risk.
**Option C:** Could be wrong if it implies that **G6PD deficiency** directly causes infections rather than increasing susceptibility through immune dysfunction.
**Why Each Wrong Option is Incorrect (continued)**
**Option D:** Would likely be incorrect if it proposes a mechanism unrelated to the **pentose phosphate pathway** or **NADPH** production.
**Clinical Pearl / High-Yield Fact**
A key point to remember is that **G6PD deficiency** can increase the risk of infections due to impaired immune cell function, which in turn can precipitate hemolytic crises. Recognizing this relationship is crucial for managing patients with **G6PD deficiency**.
**Correct Answer:** D. Impaired neutrophil function