**Core Concept:** Depression is a mental health disorder characterized by persistent feelings of sadness, loss of interest or pleasure, and a range of other cognitive and behavioral symptoms. In this scenario, the patient presents with symptoms consistent with major depressive disorder, which is a common mental health condition often triggered by stressful life events.

**Why the Correct Answer is Right:** The correct answer (C) refers to the correct diagnosis of major depressive disorder and the appropriate timing of treatment initiation following a significant life event (business loss). Depression may be triggered or exacerbated by stressful life events, such as financial setbacks. Timing is crucial because it helps differentiate between reactive depression and primary depression.

**Why Each Wrong Option is Incorrect:**

A. This option refers to a medication (fluoxetine) and not the patient management. It does not address the patient's clinical condition or when to initiate treatment.
B. This option focuses on a specific medication (fluoxetine) without considering the timing aspect of the patient's symptoms following a significant life event.
D. This option focuses on a medication (fluoxetine) but does not address the timing of treatment initiation regarding the patient's symptoms onset after a life event.

**Clinical Pearl:** Timing is essential when managing patients presenting with depressive symptoms following a significant life event. In this case, initiating treatment too early or too late may not be effective. Waiting for at least six months, after a significant life event, allows for distinguishing reactive depression from primary depression, which may have different treatment approaches. Initiating treatment too early may lead to a medication-induced worsening of the patient's symptoms.

**Correct Answer:** C. Waiting for at least six months before initiating treatment, as the symptoms appeared soon after a significant life event (business loss). After this period, initiate treatment for major depressive disorder, as the symptoms are more likely to be reactive depression rather than primary depression.