True about DNA supercoiling is all excepta) Underwinding results in negative superhelical density & supercoilingb) Superhelical density depends on length of DNAc) Underwinding strain is normally accommodated by strand separationd) Topoisomerase II change linking number in increments of 2e) Most cellular DNA is underwound

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Vikas Bhardwaj
Medical Technologist, AIIMS New Delhi
Updated: Apr 17, 2026