Suicidal enzyme is:
**Core Concept**
The suicidal enzyme is a type of enzyme that is permanently inactivated after catalyzing a single reaction. This occurs due to a covalent modification of the enzyme itself, resulting in its irreversible loss of function.
**Why the Correct Answer is Right**
The suicidal enzyme is a type of enzyme that undergoes a covalent modification after catalyzing a reaction, leading to its permanent inactivation. This is in contrast to non-suicidal enzymes that can be reactivated. The mechanism of action of suicidal enzymes involves a chemical modification of the enzyme's active site, rendering it unable to participate in further reactions. An example of a suicidal enzyme is inosine monophosphate dehydrogenase (IMPDH), which is involved in the synthesis of guanine nucleotides.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it does not accurately describe the characteristics of a suicidal enzyme.
* **Option B:** This option is incorrect because it is not a recognized term in enzymology.
* **Option C:** This option is incorrect because it is not a type of enzyme that is known to undergo suicidal inactivation.
**Clinical Pearl / High-Yield Fact**
Suicidal enzymes are often involved in the regulation of metabolic pathways, and their inactivation can have significant effects on cellular function. Understanding the mechanisms of action of suicidal enzymes is important for the development of therapeutic strategies in various diseases.
**Correct Answer: C. Inosine monophosphate dehydrogenase (IMPDH).**