D i.e. IPM Interphotoreceptor matrix (IPM) is the strongest mechanism for bonding the retina to retinal pigment epithelium (RPE)Q. It also provide physical suppo of photoreceptors and transfer nutrients and visual pigment. The quality of these functions is controlled by RPE through the synthesis of matrix materials, transpo of proteins, ions and water. Because acute alteration in degree of hydration / dehydration changes its bonding propey & viscosity. The strength of adhesion is constantly and acutely dependent on metabolism (i.e., adhesion force drops to 0 after death & reversibly restored or enhanced by tissue oxygenation). Vitreous gel pressure, intraocular fluid pressure & RPE water transpo also help in retinal adhesion.