## **Core Concept**
Streptomycin is an aminoglycoside antibiotic used to treat various bacterial infections. It works by inhibiting protein synthesis through binding to the bacterial 30S ribosomal subunit. This class of antibiotics is known for its potential to cause ototoxicity and nephrotoxicity.

## **Why the Correct Answer is Right**
The correct answer, ototoxicity, is a well-documented side effect of streptomycin. Aminoglycosides, including streptomycin, can cause damage to the inner ear structures, leading to hearing loss (auditory ototoxicity) or balance problems (vestibular ototoxicity). Streptomycin, in particular, is more associated with vestibular toxicity.

## **Why Each Wrong Option is Incorrect**
- **Option A:** While nephrotoxicity is indeed a side effect of aminoglycosides, including streptomycin, the question seems to be looking for a more specific or notable side effect directly associated with streptomycin.
- **Option B:** This option is not provided, so it cannot be evaluated.
- **Option C:** This option is not provided, so it cannot be evaluated.
- **Option D:** This option is not provided, so it cannot be evaluated.

## **Clinical Pearl / High-Yield Fact**
A key clinical pearl is that streptomycin is particularly known for its vestibulotoxicity, which can lead to significant balance issues. This is a high-yield fact because it distinguishes streptomycin from other aminoglycosides, which may have more pronounced effects on hearing.

## **Correct Answer:** . Ototoxicity