## Core Concept
Streptokinase and urokinase are thrombolytic agents used to dissolve blood clots. They work by activating plasminogen to form plasmin, which then breaks down the clot. These agents are used in conditions like acute ischemic stroke, pulmonary embolism, and myocardial infarction.

## Why the Correct Answer is Right
The correct answer, . (Recent or past gastrointestinal bleeding), is a contraindication for streptokinase and urokinase because these drugs can cause further bleeding. Thrombolytic therapy can dissolve the protective clot over an ulcer, leading to rebleeding.

## Why Each Wrong Option is Incorrect
* **Option A:** (Pregnancy) - While pregnancy is a cautious condition for many drugs, it's not an absolute contraindication for streptokinase and urokinase. They can be used if the benefits outweigh the risks, such as in severe pulmonary embolism.
* **Option B:** (Hypertension) - Uncontrolled hypertension is a concern for thrombolytic therapy due to the increased risk of bleeding, but it's not an absolute contraindication. Blood pressure needs to be controlled before administering these agents.
* **Option C:** (Diabetes) - Diabetes itself is not a contraindication for streptokinase and urokinase.

## Clinical Pearl / High-Yield Fact
A key point to remember is that a history of recent or past gastrointestinal bleeding is a significant concern for patients receiving thrombolytic therapy like streptokinase and urokinase. Always assess the risk of bleeding versus the benefit of clot lysis.

## Correct Answer: D. Recent or past gastrointestinal bleeding.