Microbiology Streptococcus toxin which is responsible for connective tissue breakdown ? A Hyaluronidase B Streptolysin 0 C Streptolysin S D Streptococcus pyogenic exotoxin 💡 Explanation Streptococcus toxin which is responsible for connective tissue breakdown ? ✓ Correct Answer: A. Hyaluronidase