Street rabies virus cause ?
**Core Concept**
Street rabies virus is a highly infectious and fatal disease caused by a lyssavirus that affects the central nervous system. The virus is primarily transmitted through the saliva of infected animals, usually through bites.
**Why the Correct Answer is Right**
The street rabies virus causes disease when it enters the body through an open wound or mucous membrane, where it multiplies and eventually reaches the central nervous system. The virus binds to nicotinic acetylcholine receptors on the surface of neurons, which triggers a series of molecular events leading to the production of new viral particles. The virus then travels to the brain, where it causes inflammation and damage to the neural tissue, leading to the characteristic symptoms of rabies, including aggression, confusion, and eventually death.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not specify the correct cause of street rabies virus.
**Option B:** This option is incorrect because it is a vague term that does not accurately describe the cause of street rabies virus.
**Option C:** This option is incorrect because it is a different type of virus that causes a different disease.
**Clinical Pearl / High-Yield Fact**
It's essential to note that post-exposure prophylaxis (PEP) with rabies immune globulin and vaccination is highly effective in preventing the development of rabies if administered promptly after exposure. However, if symptoms of rabies develop, the disease is almost always fatal.
**Correct Answer: D. Direct inoculation of virus into the wound.**