**Core Concept**
The sensation of satiety and fullness is mediated by the brain's response to signals from the gastrointestinal tract, specifically the release of hormones and neurotransmitters that regulate appetite and food intake. The brain's centers involved in appetite regulation include the hypothalamus, which has various nuclei with distinct functions.

**Why the Correct Answer is Right**
The ventromedial hypothalamus (VMH) is a key center involved in the regulation of appetite and satiety. Stimulation of the VMH produces feelings of satiety and fullness, while lesions or damage to this area can lead to hyperphagia and obesity. The VMH receives input from various sources, including the vagus nerve, which carries signals from the gastrointestinal tract, and hormones such as leptin and insulin, which provide information about energy stores.

**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not a correct answer, as the lateral hypothalamus (LH) is involved in the regulation of appetite and food intake, but its stimulation produces hunger, not satiety.
* **Option B:** This option is not a correct answer, as the parasympathetic nervous system, while involved in the regulation of digestion and appetite, does not directly stimulate a center that produces satiety with feeling of fullness.
* **Option C:** This option is not a correct answer, as the dorsal motor nucleus of the vagus nerve is involved in the regulation of parasympathetic outflow to the gastrointestinal tract, but it is not a center that produces satiety.

**Clinical Pearl / High-Yield Fact**
Damage to the ventromedial hypothalamus can lead to hyperphagia and obesity, highlighting the importance of this area in regulating appetite and food intake.

**Correct Answer: C. Ventromedial hypothalamus (VMH)**