**Core Concept**
Stereospecificity refers to the ability of enzymes to recognize and bind to specific stereoisomers, which are molecules that are mirror images of each other but non-superimposable. This property is crucial for enzymes to catalyze reactions with high specificity and efficiency.

**Why the Correct Answer is Right**
Isomerases are a class of enzymes that catalyze the rearrangement of atoms within a molecule, resulting in the formation of a new isomer. Unlike other enzyme classes, isomerases do not exhibit stereospecificity because they do not require the specific three-dimensional arrangement of atoms to catalyze the reaction. Instead, isomerases often recognize and bind to the functional group of the molecule, allowing for the isomerization of different stereoisomers. For example, the enzyme racemase catalyzes the conversion of one enantiomer to another, without showing any preference for one stereoisomer over the other.

**Why Each Wrong Option is Incorrect**
**Option A:** Oxidoreductases do exhibit stereospecificity, as they often require the specific three-dimensional arrangement of atoms to catalyze the oxidation or reduction reaction. For instance, the enzyme lactate dehydrogenase exhibits stereospecificity for the L-lactate stereoisomer.

**Option C:** Lyases also exhibit stereospecificity, as they often require the specific three-dimensional arrangement of atoms to catalyze the cleavage of a molecule. For example, the enzyme aldolase exhibits stereospecificity for the D-glyceraldehyde 3-phosphate stereoisomer.

**Option D:** Transferases exhibit stereospecificity, as they often require the specific three-dimensional arrangement of atoms to catalyze the transfer of a group. For instance, the enzyme choline kinase exhibits stereospecificity for the L-choline stereoisomer.

**Clinical Pearl / High-Yield Fact**
It's essential to remember that stereospecificity is a critical property of enzymes, and understanding its mechanisms can provide valuable insights into the regulation of metabolic pathways and the development of therapeutic strategies.

**✓ Correct Answer: B. Isomerases**