**Core Concept**
Negri bodies are characteristic cytoplasmic inclusions found in the neurons of individuals infected with rabies virus. They are a key diagnostic feature of the disease, formed through the aggregation of rabies virus antigens and host cell components.

**Why the Correct Answer is Right**
Negri bodies are indeed pathognomonic of rabies, indicating a high likelihood of the disease when observed microscopically. They are found in the brain, particularly in the neurons of the hippocampus, cerebellum, and Purkinje cells. The correct answer, however, is incorrect because Negri bodies do contain rabies virus antigen. The inclusions are composed of viral nucleocapsid proteins and host cell filaments, which are essentially aggregates of viral components.

**Why Each Wrong Option is Incorrect**
**Option A:** Negri bodies are not exclusive to rabies, as other viral infections can also produce similar inclusions. However, their presence in the context of clinical symptoms and history makes them highly suggestive of rabies.
**Option B:** While Negri bodies are primarily found in the brain, particularly in the neurons, this statement does not contribute to the inaccuracy of the correct answer.
**Option C:** This is a correct statement; Negri bodies are indeed cytoplasmic inclusions, which are a hallmark of rabies infection.

**Clinical Pearl / High-Yield Fact**
When diagnosing rabies, it is essential to consider the clinical presentation, history of exposure, and laboratory findings, including the presence of Negri bodies on histopathological examination. A rapid and accurate diagnosis is critical for effective treatment and prevention of further transmission.

**✓ Correct Answer: D. They do not contain rabies virus antigen**