**Core Concept**
Okazaki fragments are short, discontinuous DNA segments synthesized on the lagging strand during DNA replication. They are essential for replicating the lagging strand, which is antiparallel to the leading strand. Okazaki fragments are typically 1000-2000 nucleotides long and are synthesized in the 5' to 3' direction.

**Why the Correct Answer is Right**
The correct answer is related to the function and characteristics of Okazaki fragments. Okazaki fragments are synthesized by DNA polymerase delta (Pol δ) and DNA polymerase epsilon (Pol ε) enzymes, which are responsible for adding nucleotides to the growing strand. The RNA primer is removed by RNase H and DNA polymerase delta, and the gaps between Okazaki fragments are sealed by DNA ligase. Okazaki fragments are also characterized by the presence of RNA primers at their 5' ends.

**Why Each Wrong Option is Incorrect**
**Option A:** This statement is a true characteristic of Okazaki fragments. They are indeed synthesized in the 5' to 3' direction.
**Option B:** This statement is a true characteristic of Okazaki fragments. They are typically 1000-2000 nucleotides long.
**Option C:** This statement is false. Okazaki fragments are not synthesized on the leading strand. Instead, the leading strand is synthesized continuously in the 5' to 3' direction.
**Option D:** This statement is not relevant to Okazaki fragments.

**Clinical Pearl / High-Yield Fact**
Remember that Okazaki fragments are essential for replicating the lagging strand, and their synthesis is crucial for maintaining the integrity of the genome.

**Correct Answer: C. Okazaki fragments are not synthesized on the leading strand.**