All of the following statements about genetics of G6PD deficiency are true, except
**Core Concept**
G6PD deficiency is an X-linked recessive disorder caused by mutations in the G6PD gene, leading to a deficiency of the enzyme glucose-6-phosphate dehydrogenase. This enzyme is crucial for protecting red blood cells from oxidative damage. The G6PD gene is located on the X chromosome, making it more common in males who have only one X chromosome.
**Why the Correct Answer is Right**
The correct answer is related to the inheritance pattern of G6PD deficiency. The disorder is typically inherited in an X-linked recessive manner, meaning that males are more frequently affected than females. Females can be carriers of the mutated gene, but they usually do not exhibit symptoms unless they are homozygous for the mutation. The G6PD gene is highly polymorphic, with over 180 variants identified worldwide.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not specify the inheritance pattern of G6PD deficiency. While it is true that G6PD deficiency is an X-linked disorder, the statement is too vague and does not provide any useful information.
**Option B:** This option is incorrect because it does not mention the X-linked nature of G6PD deficiency. The disorder is specifically caused by mutations in the G6PD gene on the X chromosome, making this option incomplete.
**Option C:** This option is incorrect because it is true! G6PD deficiency is indeed an X-linked recessive disorder.
**Option D:** This option is incorrect because it does not specify the inheritance pattern of G6PD deficiency. While it is true that G6PD deficiency is caused by mutations in the G6PD gene, the statement is too vague and does not provide any useful information.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that G6PD deficiency is more common in males due to its X-linked recessive inheritance pattern. However, females can be carriers of the mutated gene and may pass it to their offspring.
**Correct Answer:** A. This option is the most incomplete and does not provide any useful information about the genetics of G6PD deficiency.