**Core Concept**
Amoebicides are a class of drugs used to treat amoebic infections, which are caused by the protozoan parasite Entamoeba histolytica. These drugs can be categorized into two main types: luminal amoebicides and tissue amoebicides. Luminal amoebicides act within the gastrointestinal tract, while tissue amoebicides target the amoeba in other parts of the body.

**Why the Correct Answer is Right**
Paromomycin is a luminal amoebicide, which means it acts within the gastrointestinal tract to kill the amoeba. It is effective in treating intestinal amoebiasis, but it does not penetrate the bloodstream well, making it ineffective in treating extraintestinal amoebiasis, such as liver or lung abscesses. This is why option D is the least accurate statement.

**Why Each Wrong Option is Incorrect**
**Option A:** Diloxanide furoate is indeed a luminal amoebicide, used to treat intestinal amoebiasis, so this statement is accurate.
**Option B:** Emetine is a tissue amoebicide that is contraindicated in pregnancy and patients with cardiac disease due to its potential toxicity, making this statement accurate.
**Option C:** Metronidazole is a tissue amoebicide that has some activity in the gut lumen, but it is primarily used to treat extraintestinal amoebiasis, so this statement is somewhat misleading but not entirely inaccurate.

**Clinical Pearl / High-Yield Fact**
When treating amoebiasis, it's essential to use the right type of amoebicide. Luminal amoebicides like diloxanide furoate are effective for intestinal amoebiasis, while tissue amoebicides like metronidazole are used for extraintestinal amoebiasis. This distinction is crucial for effective treatment.

**✓ Correct Answer: D. Paromomcin is effective in extraintestinal amoebiasis**