Which of the following statement is true about secondary bile acids?Rpt 2008 Q No54
**Core Concept**
Secondary bile acids are metabolites of primary bile acids, which are produced in the liver and stored in the gallbladder. They are formed by the action of intestinal bacteria on primary bile acids, and play a crucial role in the digestion and absorption of fats.
**Why the Correct Answer is Right**
Secondary bile acids, such as deoxycholic acid and lithocholic acid, are formed through the 7α-dehydroxylation of primary bile acids, specifically cholic acid and chenodeoxycholic acid. This process is catalyzed by the enzyme 7α-dehydroxylase, which is produced by intestinal bacteria. Secondary bile acids have a more hydrophobic nature than primary bile acids, which allows them to emulsify and solubilize fats more efficiently.
**Why Each Wrong Option is Incorrect**
**Option A:** This statement is incorrect because primary bile acids are produced in the liver, not secondary bile acids.
**Option B:** This statement is incorrect because the primary function of secondary bile acids is not to stimulate the secretion of pancreatic enzymes.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that secondary bile acids, particularly deoxycholic acid, can be cytotoxic and contribute to the development of colon cancer.
**Correct Answer:** C. They are formed by the action of intestinal bacteria on primary bile acids.