**Core Concept**
Post-dural puncture headache (PDPH) is a complication of dural puncture, typically occurring after procedures such as lumbar puncture or epidural anesthesia. It is characterized by a severe, debilitating headache, often accompanied by other symptoms like nausea and vomiting. The pathophysiology of PDPH involves cerebrospinal fluid (CSF) leakage through the dural defect, leading to traction on the meninges and subsequent headache.

**Why the Correct Answer is Right**
The correct answer, **D. Headache is relieved in sitting standing position**, is incorrect because post-dural puncture headache is typically exacerbated by changes in posture, particularly when moving from a recumbent to an upright position. This is due to the increased pressure gradient between the cranial and spinal compartments as a result of CSF leakage. The headache worsens when standing or sitting due to the downward displacement of the brain and subsequent traction on the meninges.

**Why Each Wrong Option is Incorrect**
**Option A:** Breach of dura is a correct statement regarding PDPH, as the headache is caused by a dural puncture or breach.
**Option B:** The onset of headache is indeed usually 12-72 hours following the procedure, making this a correct statement.
**Option C:** The headache is commonly occipito-frontal in location, which is also a correct statement, as the headache often radiates to the front of the head.

**Clinical Pearl / High-Yield Fact**
PDPH can be prevented or minimized by using atraumatic needles, reducing the number of lumbar punctures, and avoiding procedures in patients with a history of previous dural punctures or other risk factors.

**✓ Correct Answer: D. Headache is relieved in sitting standing position**