**Core Concept**
Keloids are a type of raised, thickened scar tissue that forms after injury to the skin. They are characterized by their excessive growth beyond the original wound site, often accompanied by inflammation and pain. Keloids are a result of an abnormal wound-healing process, involving an overactive inflammatory response and excessive collagen deposition.

**Why the Correct Answer is Right**
Keloids are known to be more common in individuals with darker skin types, particularly those of African or Asian descent. This is due to the increased sensitivity of melanocytes to the inflammatory mediators released during wound healing. The pathogenesis of keloids involves the overexpression of pro-inflammatory cytokines, such as TNF-α and IL-1β, which stimulate the production of collagen and other extracellular matrix components. The resulting scar tissue is often firm, rubbery, and raised above the surrounding skin.

**Why Each Wrong Option is Incorrect**
**Option A:** Keloids are typically caused by genetic predisposition, which is incorrect as keloids are multifactorial, involving both genetic and environmental factors.
**Option B:** Keloids are more common in individuals with fair skin, which is incorrect as keloids are more common in individuals with darker skin types.
**Option C:** Keloids are characterized by a lack of inflammation, which is incorrect as keloids are often accompanied by inflammation and pain.

**Clinical Pearl / High-Yield Fact**
Keloids are more likely to occur on areas of the body with high tension, such as the chest, shoulders, and back. This is due to the increased mechanical stress on the wound site, which can stimulate the overactive inflammatory response and collagen deposition characteristic of keloids.

**Correct Answer: B. Keloids are more common in individuals with fair skin.**