VB
Vikas Bhardwaj
Medical Technologist, AIIMS New Delhi
Updated: Apr 17, 2026
**Core Concept**
The question tests the understanding of **antibiotic resistance**, specifically **Methicillin-resistant Staphylococcus aureus (MRSA)**, and the appropriate antibiotic choices for treating MRSA infections.
**Why the Correct Answer is Right**
MRSA is resistant to all beta-lactam antibiotics, including Methicillin, due to an alteration in **penicillin-binding protein (PBP2a)**. Effective treatments for MRSA include **Vancomycin**, **Daptomycin**, and **Linezolid**.
**Why Each Wrong Option is Incorrect**
**Option A:** May be appropriate as some MRSA strains are sensitive to **Doxycycline** or **Clindamycin**.
**Option B:** Could be correct if it's an antibiotic effective against MRSA, such as **Vancomycin**.
**Option C:** Might be incorrect if it's an antibiotic to which MRSA is resistant, like **Ampicillin**.
**Clinical Pearl / High-Yield Fact**
Remember, **Vancomycin** is a key antibiotic for treating serious MRSA infections, and **Linezolid** can be used for skin and soft tissue infections.
**Correct Answer:** D. Ampicillin.