**Core Concept**
Sporotrichosis is a fungal infection caused by Sporothrix schenckii, characterized by its skin manifestations, typically after inoculation through a cut or scratch. The systemic or disseminated variant is a rare but severe form, requiring aggressive treatment.

**Why the Correct Answer is Right**
Amphotericin-B is a polyene antifungal agent that exerts its effect by binding to ergosterol in the fungal cell membrane, leading to cell lysis and death. In the case of systemic or disseminated sporotrichosis, Amphotericin-B is the preferred treatment due to its broad-spectrum antifungal activity and ability to penetrate into tissues and the central nervous system. This is critical in managing life-threatening infections, such as those affecting the brain, heart, or lungs.

**Why Each Wrong Option is Incorrect**
**Option A:** Itraconazole is an azole antifungal agent that is effective against various fungal infections, but it is not the first-line treatment for systemic or disseminated sporotrichosis. Its use may be considered in mild to moderate cases, but Amphotericin-B is preferred for severe or life-threatening infections.
**Option C:** Griseofulvin is an allylamine antifungal agent that is primarily used to treat dermatophyte infections, such as ringworm. It is not effective against Sporothrix schenckii and is not indicated for the treatment of sporotrichosis.
**Option D:** Saturated solution of potassium iodide (SSKI) is sometimes used to treat mild to moderate sporotrichosis, but it is not effective against the systemic or disseminated variant. SSKI works by inhibiting the conversion of iodide to iodine, which is toxic to the fungus, but its efficacy is limited in severe cases.

**Clinical Pearl / High-Yield Fact**
In cases of suspected systemic or disseminated sporotrichosis, it is essential to obtain a tissue biopsy for histopathological examination and culture to confirm the diagnosis. Prompt initiation of Amphotericin-B therapy, often in combination with other antifungal agents, is critical in preventing further dissemination and improving outcomes.

✓ Correct Answer: B. Amphotericin-B