**Core Concept**
Krause end bulbs are a type of mechanoreceptor found in the skin, responsible for detecting changes in pressure and vibration. They belong to a larger category of sensory receptors known as Merkel cell-neurite complexes.

**Why the Correct Answer is Right**
Krause end bulbs contain mechanoreceptive sensory nerve endings that respond to mechanical stimuli, such as pressure and vibration. These receptors are innervated by Aβ fibers, which transmit the sensory information to the spinal cord and brain. The activation of Krause end bulbs plays a crucial role in our ability to perceive tactile sensations, including texture and shape.

**Why Each Wrong Option is Incorrect**
**Option A:** While Meissner corpuscles are also mechanoreceptors, they are specialized for detecting low-frequency vibration and movement, not changes in pressure.
**Option B:** Pacinian corpuscles are also mechanoreceptors, but they are responsible for detecting high-frequency vibration, not pressure or texture.
**Option C:** Ruffini corpuscles are also mechanoreceptors, but they are specialized for detecting skin stretch and tension, not pressure or vibration.

**Clinical Pearl / High-Yield Fact**
It's essential to remember that Krause end bulbs are responsible for detecting changes in pressure and vibration, which is critical for our ability to perceive tactile sensations. This is why damage to the sensory nerve endings in the skin can lead to numbness and loss of sensation.

**Correct Answer:** D. Touch and pressure.