**Core Concept**
Skin tests are a crucial diagnostic tool for evaluating hypersensitivity reactions. They can demonstrate various types of hypersensitivity, including immediate hypersensitivity (Type I), delayed hypersensitivity (Type IV), and Arthus reactions (Type III). However, certain types of hypersensitivity reactions cannot be demonstrated through skin tests.

**Why the Correct Answer is Right**
The correct answer is related to the fact that skin tests are primarily used to evaluate Type I, Type IV, and Type III hypersensitivity reactions. Type II hypersensitivity reactions, also known as cytotoxic hypersensitivity, involve the binding of antibodies to cell surface antigens, leading to cell destruction. This type of reaction cannot be demonstrated through skin tests, as it requires the presence of specific antibodies and the presence of cells expressing the corresponding antigens.

**Why Each Wrong Option is Incorrect**
* **Option A:** Immediate hypersensitivity (Type I) reactions can be demonstrated through skin tests, such as the prick test or intradermal test.
* **Option B:** Delayed hypersensitivity (Type IV) reactions can be demonstrated through skin tests, such as the tuberculin skin test.
* **Option C:** Arthus reactions (Type III) can be demonstrated through skin tests, as they involve the formation of immune complexes in the skin.

**Clinical Pearl / High-Yield Fact**
Remember that Type II hypersensitivity reactions are mediated by cytotoxic antibodies, which can lead to cell destruction and tissue damage. This type of reaction is often seen in autoimmune diseases, such as hemolytic anemia, and can be a significant clinical concern.

**Correct Answer:** D.