Skin Disease not showing DIF
Correct Answer: Darrier's disease
Description: In Direct immunofluorescence, intercellular IgG -fishnet pattern throughout the epidermis is seen in pemphigus vulgaris. Benign familial pemphigus (Hailey-Hailey disease). Granular IgA at basement membrane zone and tips of papillae is seen in Dermatitis herpetiformis. Darier's disease (keratosis follicularis /darier white disease )is an autosomal dominant inherited disorder usually diagnosed by its clinical appearance of brown scaly papules in seborrhoeic areas, palmar pits, nail changes,acrokeratosis and oral lesions. A positive family history will be there. skin biopsy can also be done. Page no.323,329,287 Reference IADVL's concise textbook of dermatology
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