Site for action for disulfuram is –
Correct Answer: Aldehyde dehydrogenase
Description: Ans. is 'a' i.e., Aldehyde dehydrogenase Disulfiramo Normally alcohol is metabolized by oxidation in liver.Alcohol - AldehydeEthyl alcohol - Acetaldehyde -Acetate - CO2 +. H2ODehydrogenase - dehydrogenaseo Disulfiram inhibits the enzyme aldehyde dehydrogenase.o When alcohol is ingested after taking disulfiram, the concentration of acetaldehyde in tissues and blood rises anda number of highly distressing symptoms (aldehyde syndrome) are produced - Flushing, burning sensation,throbbing headache, perspiration, uneasiness, tightness in chest, dizziness, vomiting, visual disturbances, mentalconfusion, postural fainting and circulatory collapse,o Inhibition of aldehyde dehydrogenase with disulfiram is irreversible, synthesis of fresh enzyme is required for retumof activity.o Disulfiram inhibits a number of other enzyme as well including alcohol dehydrogenase (option b), dopaminehydroxylase and several cytochrome 450 isoenzyme.o It is used for alcohol dependence.o Side effects are rashes, acneform eruptions, urticaria, garlic like or metallic taste, mild GI disturbances, restlessness, nervousness, headache, diziness, tremor, peripheral neuropathy, psychosis and ketosis.Remembero Metabolism of alcohol follows zero order kinetics.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now