Pathology Sickle cell trait patient do not have manifestations as that of Sickle cell disease, because: A 50% HbS is required for occurrence of sickling B HbA prevents sickling C 50% sickles D HbA prevent polymerization of Hbs 💡 Explanation Sickle cell trait patient do not have manifestations as that of Sickle cell disease, because: ✓ Correct Answer: A. 50% HbS is required for occurrence of sickling