‘Bull-neck’ is seen in severe cases of which of the following?
**Core Concept**
In severe cases of diphtheria, a distinctive clinical manifestation known as 'bull-neck' or 'diphtheric neck' occurs due to the accumulation of fibrin-rich pseudomembrane on the tonsils, pharynx, and larynx. This condition is characterized by a swollen, tender, and immobile neck, often accompanied by respiratory distress.
**Why the Correct Answer is Right**
The 'bull-neck' in diphtheria is caused by the production of exotoxin by Corynebacterium diphtheriae, which leads to local tissue necrosis and inflammation. The exotoxin also damages the surrounding tissues, causing the characteristic pseudomembrane to form. This pseudomembrane is rich in fibrin, which traps bacteria and leukocytes, leading to further tissue damage and swelling. The accumulation of this pseudomembrane in the neck region results in the 'bull-neck' appearance.
**Why Each Wrong Option is Incorrect**
**Option A:** Tubercular lymphadenitis typically presents with painless, enlarged lymph nodes, usually in the cervical or axillary regions, and is not associated with a 'bull-neck' appearance.
**Option B:** Mumps can cause swelling of the parotid glands, leading to a 'chipmunk cheek' appearance, but it is not associated with a 'bull-neck'.
**Option C:** Goitre refers to an enlargement of the thyroid gland and can cause a swelling in the neck, but it does not typically present with a 'bull-neck' appearance or the characteristic pseudomembrane seen in diphtheria.
**Option D:** While a goitre can cause a swelling in the neck, it is not typically associated with the severe inflammation and tissue damage seen in diphtheria, which results in a 'bull-neck' appearance.
**Clinical Pearl / High-Yield Fact**
It's essential to note that diphtheria is a vaccine-preventable disease, and vaccination is crucial in preventing its severe manifestations, including the 'bull-neck'. Students should remember that a 'bull-neck' in a child should raise suspicion for diphtheria, especially in areas with low vaccination rates.
β Correct Answer: A. Diphtheria