A depressed patient does not want to take medication on a daily basis. The selective serotonin reuptake inhibitor (SSRI) most suitable for this patient is?
**Core Concept**
Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants that work by increasing the levels of serotonin in the brain. They are commonly used to treat depression, anxiety disorders, and other mental health conditions.
**Why the Correct Answer is Right**
The patient is unwilling to take medication on a daily basis, which suggests that they may have difficulty adhering to a daily dosing regimen. **Bupropion** is an SSRI that can be administered in a once-daily dosing regimen, making it a suitable option for this patient. Bupropion is a unique antidepressant that primarily acts by inhibiting the reuptake of norepinephrine and dopamine, rather than serotonin. This dual mechanism of action may also contribute to its efficacy in treating depression.
**Why Each Wrong Option is Incorrect**
* **Option A:** Fluoxetine is a commonly used SSRI, but it requires a daily dosing regimen, which may not be suitable for a patient who has difficulty adhering to medication.
* **Option B:** Sertraline is another popular SSRI, but it also requires daily dosing and may not be the best option for a patient who wants to minimize their medication burden.
* **Option D:** Paroxetine is an SSRI that can be administered once daily, but it has a higher side effect profile compared to bupropion and may not be the best option for a patient who is sensitive to medication side effects.
**Clinical Pearl / High-Yield Fact**
When choosing an antidepressant for a patient who has difficulty adhering to a daily dosing regimen, consider medications that can be administered less frequently, such as bupropion or mirtazapine, which can be taken once daily.
**Correct Answer:** C. Bupropion