**Core Concept**
Bronchogenic sequestration is a rare congenital anomaly where a portion of lung tissue receives its blood supply from systemic arteries, bypassing the pulmonary circulation. This condition is characterized by the presence of a non-functioning lung segment that is not connected to the airways.

**Why the Correct Answer is Right**
The most common location for bronchogenic sequestration is the lower lobe of the left lung, accounting for approximately 75% of cases. This is due to the embryological development of the lung, where the left lower lobe is more prone to maldevelopment. The sequestrated lung tissue typically receives its blood supply from the aorta or its branches, such as the thoracic aorta or the intercostal arteries.

**Why Each Wrong Option is Incorrect**
**Option A:** The right upper lobe is not a common location for bronchogenic sequestration, which makes it an unlikely choice.
**Option B:** The middle lobe is not typically involved in bronchogenic sequestration, as it is a smaller and less commonly affected lobe.
**Option C:** The right lower lobe is occasionally involved, but it is less common than the left lower lobe.

**Clinical Pearl / High-Yield Fact**
Bronchogenic sequestration can be mistaken for other lung conditions, such as pneumonia or lung abscess, so it is essential to consider this diagnosis in patients with unexplained respiratory symptoms and a systemic arterial supply to the lung tissue.

**Correct Answer:** D. Lower lobe of left lung.