Septicaemic shock with multi-organ failure is treated by
**Core Concept**
Septicaemic shock is a life-threatening condition characterized by an overwhelming systemic inflammatory response to infection, leading to cardiovascular collapse and multi-organ dysfunction. The primary goal of treatment is to restore circulatory stability, eliminate the source of infection, and provide adequate organ support.
**Why the Correct Answer is Right**
The treatment of septic shock involves the administration of vasopressors to maintain adequate blood pressure and organ perfusion. Norepinephrine is often the preferred initial vasopressor due to its potent vasoconstrictive properties and ability to increase cardiac output. Additionally, fluid resuscitation is crucial to restore circulating volume and improve cardiac preload. The use of vasopressors and fluids is guided by hemodynamic monitoring, including central venous oxygen saturation (ScvO2) and lactate levels.
**Why Each Wrong Option is Incorrect**
**Option A:** Corticosteroids may be considered in septic shock, particularly if there is evidence of adrenal insufficiency or refractory hypotension. However, they are not typically used as the primary treatment for septic shock.
**Option B:** Broad-spectrum antibiotics are essential in treating septic shock, but they are not the primary treatment for the condition itself.
**Option C:** Vasopressin may be used as an adjunctive therapy in septic shock, particularly if there is refractory hypotension. However, it is not typically used as the primary treatment for septic shock.
**Clinical Pearl / High-Yield Fact**
In septic shock, the goal of fluid resuscitation is to restore a mean arterial pressure (MAP) of at least 65 mmHg and a ScvO2 of 70% or higher. This can be achieved by administering crystalloid fluids, such as lactated Ringer's solution, and monitoring hemodynamic parameters closely.
**Correct Answer: C. Norepinephrine**