**Question:** All of the following are features of Grave's disease except: September 2005

A. Hyperthyroidism
B. Thyroid storm
C. Thyroid eye disease
D. Myxedema

**Correct Answer:** D. Myxedema

**Core Concept:** Grave's disease is an autoimmune disorder characterized by overproduction of thyroid hormones (hyperthyroidism) due to the presence of specific antibodies targeting the thyroid gland. It is associated with three main clinical features:

**Why the Correct Answer is Right:** Myxedema is a condition characterized by low thyroid hormone levels (hypothyroidism) and is typically caused by iodine deficiency or destruction of the thyroid gland. In contrast, Grave's disease presents with hyperthyroidism due to autoimmune stimulation of thyroid gland.

**Why Each Wrong Option is Incorrect:**

A. Hyperthyroidism (Hyperthyroidism is a feature of Grave's disease, making option A incorrect.)
B. Thyroid storm (Thyroid storm is a severe complication of hyperthyroidism, not a feature of Grave's disease.)
C. Thyroid eye disease (Also known as Graves' orbitopathy, this is a common extrathyroidal manifestation of Grave's disease, making option C not a correct answer.)

**Clinical Pearl:** Understanding the various features of Grave's disease is crucial for accurate diagnosis and proper treatment planning. Misdiagnosis could lead to incorrect treatment strategies and potential complications. Always ensure to consider the specific clinical features and laboratory findings associated with each condition before reaching a diagnosis.