**Core Concept**
In Hansen's disease (leprosy), the earliest sensation to be lost is due to the involvement of the peripheral nerves, specifically the sensory nerves, which are responsible for transmitting sensory information from the skin to the central nervous system.

**Why the Correct Answer is Right**
The correct answer is related to the pathophysiology of Hansen's disease, which involves the destruction of peripheral nerves by the leprosy bacillus (Mycobacterium leprae). The sensory nerves are affected early in the disease, leading to loss of sensation in the affected areas. This is due to the destruction of the myelin sheath and the axons of the sensory nerves, resulting in a loss of nerve conduction velocity and ultimately, loss of sensation.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because Hansen's disease primarily affects the peripheral nerves, not the autonomic nerves.
**Option B:** This option is incorrect because while motor nerves can be affected in Hansen's disease, the earliest sensation to be lost is sensory.
**Option C:** This option is incorrect because the loss of sensation in Hansen's disease is due to the destruction of sensory nerves, not the compression of nerves.

**Clinical Pearl / High-Yield Fact**
In Hansen's disease, the loss of sensation is often asymmetrical and may be accompanied by skin lesions and nerve thickening.

**Correct Answer: B. Temperature and pain sensation**