**Core Concept**
The question tests the student's knowledge of nonsteroidal anti-inflammatory drugs (NSAIDs), specifically the **cyclooxygenase-2 (COX-2) inhibitors**. COX-2 is an enzyme involved in the production of prostaglandins, which are key mediators of inflammation and pain.

**Why the Correct Answer is Right**
Selective COX-2 inhibitors are a class of NSAIDs designed to reduce the gastrointestinal side effects associated with traditional NSAIDs by selectively inhibiting the COX-2 enzyme, thereby reducing prostaglandin production in inflammatory tissues. This selectivity is intended to preserve the protective prostaglandins in the gastrointestinal tract, which are primarily produced by the COX-1 enzyme.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not specify a selective COX-2 inhibitor.
**Option B:** This option is incorrect as it is not a recognized selective COX-2 inhibitor.
**Option C:** This option is incorrect because it refers to a different class of drugs.
**Option D:** This is not provided, but typically, options that are not selective COX-2 inhibitors would be incorrect.

**Clinical Pearl / High-Yield Fact**
A key point to remember is that while selective COX-2 inhibitors like **celecoxib** reduce gastrointestinal side effects, they may increase the risk of cardiovascular events, making them a less favorable choice for patients with certain cardiovascular risk factors.

**Correct Answer:** D. Celecoxib.