Sections from a solid-cystic unilateral ovarian tumor in a 30-year old female show a tumor composed of diffuse sheets of small cells with doubtful nuclear grooving and scanty cytoplasm. No C -Exner bodies are seen. The ideal immunohistochemistry panel would include –
Correct Answer: Vimentin, epithelial membrane antigen, inhibin, CD99
Description: This patient is having granulosa cell tumor of the ovary which is characterized histologically by :
Diffuse sheets of round and oval cells
Inconspicuous groove and folds in nuclei - coffee bean appearance
Scant cytoplasm
Granulosa cell tumor is positive for →
(i) Vimentin, (ii) Inhibin, (iii) CD99
Epithelial membrane antigen is positive in surface epithelial tumor.
Category:
Pathology
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