## Core Concept
A screening test is a preliminary assessment used to identify individuals who may have a specific disease or condition before they present with symptoms. The key characteristics of a screening test include its sensitivity, specificity, positive predictive value, and negative predictive value. Screening tests are crucial for early detection and intervention.

## Why the Correct Answer is Right
The correct answer, ., implies that one of the statements provided is not true for a screening test. Typically, screening tests are evaluated based on their ability to correctly identify those with and without the disease (sensitivity and specificity), their predictive values, and the impact on health outcomes. Without the specific statements, we focus on general principles: Screening tests should ideally have high sensitivity to catch as many cases as possible and high specificity to minimize false positives. They should also be easy to administer, inexpensive, and acceptable to the population.

## Why Each Wrong Option is Incorrect
- **Option A:** Without the specific details of option A, we can't directly address why it's incorrect. However, if option A stated a desirable characteristic of a screening test, such as being sensitive or specific, and this is indeed a true statement, then it would not be the correct answer to the question about which statement is not true.
- **Option B:** Similarly, if option B presented a true statement regarding screening tests, it would not be the correct answer.
- **Option C:** This option would also be incorrect if it represented a true characteristic of screening tests.

## Clinical Pearl / High-Yield Fact
A key point to remember is that no screening test is perfect. The **trade-off between sensitivity and specificity** is crucial; increasing one often decreases the other. Screening tests with high sensitivity but lower specificity are often used for initial screening (e.g., PSA for prostate cancer), followed by more specific confirmatory tests.

## Correct Answer Line
**Correct Answer: D.**